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Pomegranate Juice for PSA-only Prostate Cancer Recurrence
Phase III Randomized Study of Pomegranate Juice in Patients With Rising Prostate-Specific Antigen Levels After Surgery or Radiotherapy for Localized Prostate Cancer (UCLA-0507059-01). See the protocol summary.
Dr. Allan Pantuck and Dr. Arie Belldegrun, Jonsson Comprehensive Cancer Center at UCLA.
Surgery and radiotherapy are common treatments for localized prostate cancer (cancer confined to the prostate gland). Following such treatments, doctors may monitor the blood level of a protein called prostate-specific antigen (PSA). An increase in PSA level may be an early indicator that prostate cancer has returned. Research has shown that the length of time it takes for a rising PSA level to double (called PSA doubling time) can be useful in predicting the risk of prostate cancer progression and death.
Currently, there is no standard treatment for men who have recurrent prostate cancer detected by an increase in PSA level only. Consequently, doctors want to develop treatments that can slow down or reverse increases in PSA without causing serious side effects.
In this trial, researchers are exploring the potential of pomegranate juice to slow or reverse increasing PSA levels in men who have undergone treatment for localized prostate cancer. Pomegranate juice is rich in phytochemicals, substances that have been shown in laboratory studies to inhibit cancer growth and spread. Men in this trial will be randomly assigned to drink a special preparation of pomegranate juice or a placebo drink daily for up to one year.